PEDIATRICS Vol. 30 No. 3 September 1962, pp. 350-360
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TEMPERATURE REGULATION IN INFANTS WITH CHRONIC HYPOXEMIA

Kurt Brück M.D.1, Forrest H. Adams M.D.1, and Monika Brück M.D.1

1 Department of Pediatrics, University of California Medical Center, Los Angeles, California, and the Department of Physiology, University of Marburg, Marburg-Lahn, Germany

The temperature regulation in 10 young infants with various degrees of chronic hypoxemia was studied. In most of the patients the hypoxemia was due to cardiac malformations. It was demonstrated that even infants whose arterial oxygen content was as low as 5 vol % were still able to respond with an increase of oxygen consumption, when they were exposed to environmental temperatures below the neutral temperature. The magnitude of the increased oxygen consumption, however, was reduced in those infants who also had heart failure and in those whose arterial oxygen content was below 10 vol %. Skin blood flow was reduced on cooling, indicating that the hypoxemia had not interfered with the vascular mechanisms of temperature regulation. It can be stated from these experiments that the neutral temperature as determined for normal young infants is also an appropriate environmental temperature for unclothed infants with hypoxemia, since the oxygen demand is minimal under these conditions.




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