PEDIATRICS Vol. 30 No. 1 July 1962, pp. 17-26
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MEDICAL THERAPY OF THYROTOXICOSIS IN CHILDREN

Wellington Hung M.D.1, Lawson Wilkins M.D.1, and Robert Blizzard M.D.1

1 Division of Pediatric Endocrinology of the Department of Pediatrics, Johns Hopkins University School of Medicine and the Harriet Lane Home of the Johns Hopkins Hospital, Baltimore 5, Maryland

This report concerns 34 children and adolescents with hyperthyroidism who were treated with anti-thyroid drugs in the Endocrine Clinic of the Harriet Lane Home. In all instances except when there was drug sensitivity (two cases) or lack of co-operation (one case), anti-thyroid therapy was successful in establishing and maintaining a euthyroid state. Nineteen of 25 patients who were treated for a 2-year period remained well after discontinuing all therapy. Two of the remaining six patients relapsed and subsequently were thyroidectomized, two relapsed and resumed medical treatment, and two have not discontinued therapy. Nine patients did not complete 2 years of therapy, thyroidectomy was performed in three, and a fourth relapsed after discontinuing therapy after 8 months. Five patients are currently receiving anti-thyroid therapy but have been treated less than 2 years. Although we realize that some of the 19 patients who are in remission may relapse at some future date, 13 have remained well for 1 to 13 years after discontinuing therapy. On the basis of these favorable responses we believe that surgical therapy of thyrotoxic children should be reserved for those patients who fail to co-operate or who relapse after prolonged medical therapy. In addition to the data discussed above, results concerning the triiodothyronine suppression tests and the incidence of antithyroid antibodies in thyrotoxic children are presented and discussed.




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