PEDIATRICS Vol. 3 No. 5 May 1949, pp. 645-650
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INTESTINAL ABSORPTION OF VITAMIN A FROM OILY AND AQUEOUS MEDIA IN PATIENTS WITH THE CELIAC SYNDROME

WAYNE H. DANIELSON PH.D.1, EDWARD L. BINKLEY M.D.1, and HAROLD D. PALMER M.D.1

1 Children's Hospital, Denver, Colo.

The absorption of vitamin A from oily and aqueous media has been studied in infants and children with cystic fibrosis of the pancreas and idiopathic celiac disease.

Patients with cystic fibrosis of the pancreas can absorb vitamin A acetate and vitamin A alcohol when it is given to them in an aqueous dispersion. The vitamin A acetate curves rose above the vitamin A alcohol curves in three of four patients on whom absorption curves were obtained.

Vitamin A is absorbed by patients with idiopathic celiac disease only slightly better from an aqueous dispersion of the alcohol than from an oily concentrate of the naturally occurring esters. The poor absorption from an aqueous media by these patients supports the suggestion that the defect in absorption in this disease lies within the intestinal mucosa.

The use of the differences in response to oily and aqueous concentrates in the differential diagnosis of the entities of the celiac syndrome is suggested.

Submitted on August 16, 1948