PEDIATRICS Vol. 3 No. 4 April 1949, pp. 418-422
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RENAL CLEARANCES OF SODIUM PENICILLIN G, PROCAINE PENICILLIN G, AND INULIN IN INFANTS AND CHILDREN

HENRY L. BARNETT M.D.1, HELEN MCNAMARA M.A.1, SELMA SHULTZ M.A.1, and RALPH TOMPSETT M.D.1

1 The New York Hospital and the Departments of Pediatrics and Medicine, Cornell University Medical College, New York, N.Y.

Reports of unexpectedly high serum concentrations of procaine penicillin G suggested the possibility that, in addition to the major factor of slow absorption, the renal clearance of procaine penicillin might be lower than that of the sodium salt.

Measurements of inulin clearances and clearances of either sodium penicillin G or procaine penicillin G in 10 children and four premature infants showed no significant difference between the clearances of the two penicillin salts. A reduced clearance of procaine penicillin, therefore, does not explain the apparent occurrence of unexpectedly high serum concentrations of penicillin in normal subjects.

Critical evaluation of data on the maintenance of drug levels with a particular preparation of procaine penicillin requires consideration of the limits imposed by the clearance data presented.

Penicillin clearances in premature infants suggest that if penicillin is given to small infants in dosages proportionate to their surface area, the duration of drug concentrations in the blood should be six times as long as in children and adults and three times as long if the dosage is proportionate to body weight.

Submitted on July 26, 1948




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