PEDIATRICS Vol. 3 No. 2 February 1949, pp. 157-176
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SEPSIS OF OBSCURE ORIGIN IN THE NEWBORN

WILLIAM A. SILVERMAN M.D.1 and WILLIAM E. HOMAN M.D.1

1 The Department of Pediatrics, College of Physicians and Surgeons, Columbia University, and the Babies Hospital, New York City.

Twenty-five cases of sepsis in the first month of life, without preceding major illness, have been collected over an 11-year period at the Babies Hospital. A high incidence of males was noted. Fever, jaundice, and pyelonephritis were the most common manifestations. Five cases were observed to have an increase of lymphocytes in sterile spinal fluid. Coliform organisms were responsible for the majority of the infections. Thirty-five comparable cases were assembled from the literature. Neither this series nor the collected published evidence afforded statistical proof of the efficacy, or the lack of efficacy, of present day therapy in this syndrome of sepsis of obscure origin. Recommendations for work-up and initial therapy are offered.

Submitted on June 29, 1948




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