PEDIATRICS Vol. 29 No. 3 March 1962, pp. 442-447
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EXPERIMENTAL SALICYLATE INTOXICATION

I. Comparison of Exchange Transfusion, Intermittent Peritoneal Lavage, and Hemodialysis as Means for Removing Salicylate

J. A. James M.B., M.R.C.P.1, Lewis Kimbell B.S.1, and William T. Read M.D.1

1 Department of Pediatrics, the University of Texas Southwestern Medical School, Dallas, Texas

Exchange transfusion, hemodialysis and peritoneal dialysis with albumin and conventional dialysis solutions was carried out in dogs following the administration of a standard dose of sodium salicylate intravenously. Hemodialysis was the most efficient method of removing salicylate, about 50% of the dose injected being removed during a 4-hour period. Exchange transfusion and peritoneal lavage were considerably less efficient. Peritoneal lavage with 5% albumin solution was more effective than lavage with an equal volume of conventional dialysis solution, but absorption of albumin from the peritoneum took place unless additional dextrose was added to the solution. The amount of salicylate excreted in the urine during the period of study sometimes exceeded that removed by peritoneal dialysis or exchange transfusion. Some clinical implications of these studies are discussed.