PEDIATRICS Vol. 28 No. 6 December 1961, pp. 946-949
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OCCURRENCE OF CONGENITAL ADRENAL HYPERPLASIA IN HALF SISTERS

Geoffrey C. Robinson M.D., F.R.C.P.(C)1, James R. Miller Ph.D.1, and Hamish W. McIntosh M.S.C., M.D., F.R.C.P.(C)1

1 Department of Pediatrics, University of British Columbia, Vancouver, Canada

The occurrence of female pseudohermaphroditism due to congenital adrenal hyperplasia in half sisters is described. It is concluded that the disease is transmitted by autosomal recessive genes. The mother, herself a heterozygote, was unfortunate in that her two husbands each were heterozygous for the mutant gene in question.