PEDIATRICS Vol. 28 No. 4 October 1961, pp. 592-601
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STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT

IV. The Effect of Glucagon on the Capillary Blood Sugar in Infants of Diabetic Mothers

Marvin Cornblath M.D.1, Demetrios Nicolopoulos M.D.1, Angelita F. Ganzon M.D.1, Ephraim Y. Levin M.D.1, Mordecai H. Gordon Ph.D.1, and Harry H. Gordon M.D.1

1 Departments of Pediatrics of Sinai Hospital of Baltimore and Johns Hopkins Medical Institutions

Glucagon in varying doses was given to 40 infants born to diabetic mothers, and the blood sugar concentrations were determined at intervals thereafter. Glucagon (30 µg/kg) produced a hyperglycemia in vaginally delivered infants but not in those delivered by cesarean section. Glucagon (300 µg/kg) produced a hyperglycemia in infants delivered by cesarean section. Distressed infants seemed to respond less well than those who had an uneventful course. The data are interpreted as indicating the desirability of avoiding generalizations concerning all infants of diabetic mothers.