PEDIATRICS Vol. 27 No. 6 June 1961, pp. 912-920
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STUDIES IN THE PHYSIOLOGY OF SWEATING IN CYSTIC FIBROSIS

I. Experimental Sweat Gland Fatigue

Maarten S. Sibinga M.D.1 and Giulio J. Barbero M.D.1

1 The Children's Hospital of Philadelphia, and Department of Pediatrics, School of Medicine, University of Pennsylvania

With repeated methacholine (Mecholyl) chloride stimulation, experimental sweat gland fatigue was induced in 21 control subjects and 19 patients with cystic fibrosis of the pancreas. The relationship between rate of secretion and concentration of sodium in sweat was studied in these experiments. A concept of two different types of sweat gland fatigue was developed, based on the anatomic parts of the sweat gland.

Sweat glands of patients with cystic fibrosis are subject to fatigue much like normal glands. An earlier decline in sweating rate during the experimental sweat gland fatigue was observed in patients with cystic fibrosis, showing a greater sensitivity to intense stimulation.

Although greater variability in concentration of sodium was observed in patients with cystic fibrosis undergoing a sweat gland fatigue experiment, the over-all fatigue response in both groups was comparable. Tubular function was not interpreted to be abnormal, but an abnormality in the coil seems to be a possible site for the secretory defect in cystic fibrosis. Under intense stimulation the sweat of patients with cystic fibrosis varies with factors that operate in the normal sweat gland. Sweat glands of patients with cystic fibrosis, however, are more unstable in relation to concentration of sodium than are normal sweat glands.


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