PEDIATRICS Vol. 27 No. 5 May 1961, pp. 790-799
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SYSTEMIC MANIFESTATIONS DUE TO ALLERGY

Report of Fifty Patients and a Review of the Literature on the Subject (Sometimes Referred to as Allergic Toxemia and the Allergic Tension-Fatigue Syndrome)

William G. Crook M.D.1, Walton W. Harrison M.D.1, Stanley E. Crawford M.D.1, and Blanche S. Emerson M.D.1

1 The Children's Clinic, Jackson, Tennessee

The data on 50 patients with systemic manifestations due to allergy seen at the Children's Clinic, Jackson, Tennessee, during the period 1956 through 1960 is presented. Detailed case histories are recorded for four of these patients. The findings on the remainder are given in tabular form.

Uniformly, the symptoms and signs in these children were fatigue, irritability, pallor in the absence of anemia, and infraorbital circles. Most of them also had nasal congestion, abdominal pain and headache. A variety of other signs and symptoms, including those of nervous system involvement, may also be present.

The literature on this condition is reviewed in detail showing that this condition has been described under several different names by many observers during the past 40 years. In spite of these descriptions, few physicians are aware that allergy causes such systemic manifestations.

In conclusion, it is suggested that allergy be included in the differential diagnosis of any child with generalized body symptoms of undetermined cause.




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