PEDIATRICS Vol. 26 No. 4 October 1960, pp. 722-723
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Lack of Inhibition of Choline Esterase in Serum by Nupercaine in Cystic Fibrosis

Ione Weber Ph.D.1, George A. Hayden B.A.1, Ih Chin Kim M.D.1, and Giulio J. Barbero M.D.1

1 Children's Hospital of Philadelphia Philadelphia 46, Pa.

When it was reported1 that a genetic factor was involved in the degree of inhibition of choline esterase activity in the serum by Dibucaine (nupercaine), a study was undertaken to determine whether or not this familial characteristic could be demonstrated in patients with cystic fibrosis and their relatives, as contrasted with the general population.

The ages of the 31 patients with cystic fibrosis ranged from 18 days to 9 years. The relatives comprised: 28 mothers, ages 20 to 49 years; 23 fathers, ages 23 to 54 years; 10 siblings, ages 2frac12 to 20 years; and 43 other relatives, ages 5 to 72 years.