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PEDIATRICS Vol. 26 No. 4 October 1960, pp. 630-640
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LIVER FUNCTION TESTS IN INFANTS WITH BILIARY ATRESIA

Report of 30 Cases

Jesus Kumate M.D.1, Francisco Beltrán M.D.1, Lázaro Benavides M.D., M.P.H.1, , Marí Antonieta Flores Q.F.B.1

1 Departamento de Infectología and Departamento de Cirugía, Hospital Infantil, Mexico City

Simultaneous changes of serum bilirubin (direct/total ratio), flocculation tests (thymol and cephalin-cholesterol), transaminases (GOT and GPT), serum cholinesterase and serial clearance of BSP were studied in 30 cases of biliary atresia confirmed by exploratory laparotomy or necropsy.

Serum bilirubin generally showed a tendency to increase as age advanced (more evident after the fourth month) although its correlation was poor (r = 0.31). In over 80% of the cases, the direct/total ratio was 0.50 or greater.

Flocculation tests showed abnormal values in over 35% of the cases and were more marked as age and degree of malnutrition increased.

Transaminase activities in the serum showed slight increases (about 100 units/ml), predominantly of GOT and without relation to age, nutritional condition or flocculation tests.

Subnormal activity of cholinesterase was observed in three-fourths of the cases; it was more evident in older patients and no relation was found to percentage of the patient's theoretic weight.

Serial study of BSP clearance showed increase of retention at 45 minutes (about 30%) and exponential elimination (with a half-life of 2.4 days) and levels above 6% by the fifth day following administration of the dye.


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Home page
 Arch Pediatr Adolesc MedHome page
A. M. RUTENBURG, E. P. PINEDA, J. A. GOLDBARG, R. LEVITAN, S. S. GELLIS, and M. SILVERBERG
Serum Leucine Aminopeptidase: Activity in Normal Infants, in Biliary Atresia, and in Other Diseases
Arch Pediatr Adolesc Med, January 1, 1962; 103(1): 47 - 54.
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