PEDIATRICS Vol. 26 No. 2 August 1960, pp. 190-199
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STUDIES ON HUMAN PROTEINURIA

I. The Mechanism of Postural Proteinuria

R. J. Slater M.D.1, N. J. O'Doherty M.D. (N.U.I.), M.R.C.P.1, and M. S. DeWolfe M.A.1

1 Research Institute of The Hospital for Sick Children, and the Department of Paediatrics, Faculty of Medicine, University of Toronto

Observations on the transfer of labelled albumin from plasma into urine were made in five children with postural proteinuria. Transfer of labelled protein occurs rapidly during lordosis. During the period of decreasing proteinuria that occurs upon cessation of lordosis, no transfer of labelled protein could be observed. These findings suggest that the functional alteration causing postural proteinuria is rapidly reversible, occurring only during the orthostasis. Despite the similarity in composition of proteins in postural proteinuria and in lymph, the rates of protein transfer and the similar specific activity of serum and urinary protein suggest that the site of transfer is the glomerular capillary.

Immunologic study of the urinary proteins indicate that the ggr-globulin excreted in postural proteinuria is similar to that of serum, in contrast to the ggr-globulin excreted in exercise proteinuria and "normal" urinary protein which reveal altered characteristics.