PEDIATRICS Vol. 24 No. 5 November 1959, pp. 856-858
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WOOLLEY, P. V.
Right arrow Search for Related Content
PubMed
Right arrow Articles by WOOLLEY, P. V.

Skeletal Changes Associated with Increased Vitamin A Ingestion

PAUL V. WOOLLEY M.D.1

1 Children's Hospital of Michigan, 5224 St. Antoine St., Detroit 2, Michigan.

Dr. C. L. Mitchell, chief of the orthopedic section at the Henry Ford Hospital, has sent me a copy of the April, 1959, number of the Bulletin of the Hospital for Special Surgery containing an article by John B. Griffin entitled, Hypervitaminosis A.

This report describes briefly three children (twins [fraternal] aged 2 years; the other 19 months) with painful limps. Each is purported to have received about 200,000 units daily of "water soluble" vitamin A from roughly 4 months of age to the first birthday. The bony changes described and illustrated are limited to cupping of the metaphyses so that the distal epiphyses of the femurs (and in one illustration, of the tibia) appear imbedded within or sunken into the substance of the diaphysis.