PEDIATRICS Vol. 24 No. 5 November 1959, pp. 854-855
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Letters to the Editor

DAVID W. ANDERSON PH.D.1 and HARTLEY W. HOWARD PH.D.1

1 Pharmaceutical Division, The Borden Company, New York 17, New York

Van Wyk et al. have reported a case of goiter and hypothyroidism in an infant maintained 8 months on a diet of soybean milk (Mull-Soy®). Their studies of this case and comparison with apparently normal individuals have led them to infer the presence in soy of a goitrogen which, in susceptible persons, modifies thyroid metabolism.

We are studying the effect of soybean products on thyroid activity in rats and it seems desirable to present certain preliminary observations at this time.

Rats, housed in individual wire-screen cages, were fed diets simulating soybean milk in composition and fortified with vitamins and iron to meet the known requirements. Water, ion-exchanged to remove traces of iodine, was provided ad libitum.