PEDIATRICS Vol. 24 No. 5 November 1959, pp. 746-751
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CONCENTRATION OF GAMMA-GLOBULIN IN THE SERUM OF INFANTS DURING THE FIRST 3 MONTHS OF LIFE

Virginia E. Trevorrow Ph.D.1

1 Child Research Council and University of Colorado Medical School

Studies of gamma-globulin on 16 infants at ages 3 days, 1, 2, and 3 months show a drop in concentration which results primarily from dilution in an expanding plasma volume. The total circulating gamma-globulin remains relatively constant from age 3 days through the first 3 months of life. As degradation of protein is probably taking place, it is concluded that the normal loss is being replaced by synthesis by the infant.

Submitted on March 17, 1959
Accepted on July 27, 1959