PEDIATRICS Vol. 24 No. 2 August 1959, pp. 181-193
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STUDIES OF RESPIRATORY PHYSIOLOGY IN CHILDREN

II. Lung Volumes and Mechanics of Respiration in 64 Patients with Cystic Fibrosis of the Pancreas

C. D. Cook M.D.1, P. J. Helliesen M.D.1, L. Kulczycki M.D.1, H. Barrie M.D.1, L. Friedlander M.D.1, S. Agathon B.A.1, G. B. C. Harris M.D.1, and H. Shwachman M.D.1

1 Department of Pediatrics, Harvard Medical School and the Departments of Medicine, Radiology and Clinical Laboratories of the Children's Medical Center, Boston

Tidal volume, respiratory rate and lung volumes have been measured in 64 patients with cystic fibrosis of the pancreas while lung compliance and resistance were measured in 42 of these. Serial studies of lung volumes were done in 43.

Tidal volume was reduced and the respiratory rate increased only in the most severely ill patients. Excluding the three patients with lobectomies, residual volume and functional residual capacity were found to be significantly increased in 46 and 21%, respectively. These changes correlated well with the roentgenographic evaluation of emphysema. Vital capacity was significantly reduced in 34% while total lung capacity was, on the average, relatively unchanged. Seventy per cent of the 61 patients had a signficantly elevated RV/TLC ratio.

Lung compliance was significantly reduced in only the most severely ill patients but resistance was significantly increased in 35% of the patients studied. The serial studies of lung volumes showed no consistent trends among the groups of patients in the period between studies. However, 10% of the surviving patients showed evidence of significant improvement while 15% deteriorated. [See Fig. 8. in Source Pdf.]

Although there were individual discrepancies, there was a definite correlation between the clinical evaluation and tests of respiratory function, especially the changes in residual volume, the vital capacity, RV/ TLC ratio and the lung compliance and resistance.

Submitted on January 2, 1959
Accepted on March 9, 1959