PEDIATRICS Vol. 23 No. 5 May 1959, pp. 945-947
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FAILURE OF SULFONAMIDES TO INCREASE THE THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN THE TREATMENT OF STREPTOCOCCAL INFECTIONS

Burtis B. Breese M.D.1, Frank A. Disney M.D.1, and William B. Talpey M.D.1

1 Department of Pediatrics, the University of Rochester School of Medicine and Dentistry

A group of children with beta hemolytic streptococcal infections were divided by lot into two comparable groups. One was treated with penicillin orally, the other with penicillin plus a sulfonamide. No difference could be found in the initial response to therapy or the subsequent recurrence or carrier rate in the two groups.

It is therefore concluded that, in the treatment of streptococcal infections in children, the addition of a sulfonamide to penicillin offers no therapeutic advantage.

Submitted on August 29, 1958
Accepted on October 28, 1958