PEDIATRICS Vol. 23 No. 5 May 1959, pp. 835-836
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by STOHLMAN, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by STOHLMAN, F., JR.

ERYTHROPOIETINE

FREDERICK STOHLMAN JR. M.D.1

1 National Institute of Arthritis and Metabolic Diseases Bethesda 14, Md.

ERYTHROPOIETINE is a protein, capable of stimulating erythrocyte production, which is found in the plasma of animals subjected to hypoxia or following the administration of cobalt. Sufficient data have been accumulated in the more common hematologic disorders to draw some tentative conclusions about its etiologic and therapeutic significance in clinical medicine.

The highest concentrations of erythropoietine have been observed in diseases associated with erythroid aplasia. Substantial levels have been observed in congenital hypoplastic anemia, aplastic anemia, marrow aplasia due to chloramphenicol, and acute lymphocytic leukemia.

In diseases associated with hemolysis and erythroid hyperplasia, such as Cooley's erythroblastic anemia and sickle cell disease, concentrations of erythropoietine in the plasma are not as high as in patients with similar hemoglobin levels due to aplasia.