PEDIATRICS Vol. 23 No. 4 April 1959, pp. 662-675
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INCREASED AMINO-ACIDURIA IN INFANTS WITH KWASHIORKOR FED NATURAL AND SYNTHETIC DIETS

Harold E. Schendel Ph.D.1, Arnold Antonis Ph.D.1, and John D. L. Hansen M.B., M.R.C.P.1

1 Clinical Nutrition Research Unit, Department of Medicine, and Department of Pediatrics, University of Cape Town, South Africa

There appears to be a temporarily increased (three-to eightfold) amino-aciduria in kwashiorkor, which is rapidly reduced with treatment. This increased excretion was apparent when the data were expressed as a function of body weight or excretion of creatinine, as a percentage of intake or as amino-acid index. Further, this increase is due to the increased output of 17 amino acids rather than any single acid.

Secondly, there is a grossly increased amino-aciduria in both normal infants and infants with kwashiorkor fed two synthetic amino-acid formulae, theoretically adequate: this appears to be due to a large extent to those acids present in the formula as the DL-isomers, although excretion of D-acids was also higher in the patients with kwashiorkor than in controls.

Submitted on August 13, 1958
Accepted on September 23, 1958