PEDIATRICS Vol. 23 No. 3 March 1959, pp. 606-617
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ENZYMATIC PATTERNS DURING DEVELOPMENT

An Approach to a Biochemical Definition of Immaturity

Norman Kretchmer M.D., Ph.D.1

1 Department of Pediatrics, New York Hospital-Cornell Medical Center

I would like to express my gratitude to you, the American Academy of Pediatrics, for selecting me for an E. Mead Johnson Award. I accept the honor with humility because no scientific work is accomplished without inspiration from teachers and other investigators, and without actual participation of many colleagues. I appreciate this opportunity to acknowledge publicly those individuals who have been and are particularly influential in my progress.

Dr. Jean Oliver, the man to whom I owe my entry into medicine and pediatrics, with great effort instilled in me an everlasting appreciation for the inseparable relationship between structure and function. Fortunately, I have remained in close contact with Dr. Oliver throughout the years, continually reaping benefits from his advice and influence.

I conceived of function as only cellular and molecular until Dr. Henry L. Barnett introduced me to organ function, especially in relation to the young individual. In addition, he fostered in me an interest in the broader aspects of pediatrics, amid since that time has been available constantly for intimate exchange and crystallization of ideas.

I am indebted particularly to Dr. S. Z. Levine for leading me into the field of biologic development and insisting that my time be divided between clinical pediatrics and the laboratory. Dr. Levine has always emphasized that ideas, philosophies and problems originating in the ward or clinic can and should be considered in the laboratory.




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