PEDIATRICS Vol. 23 No. 3 March 1959, pp. 550-552
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THE PERSISTENCE OF POLIOMYELITIS ANTIBODIES AFTER PRIMARY IMMUNIZATION OF YOUNG INFANTS

Randolph Batson M.D.1, Amos Christie M.D.1, Dorothy Turner 1, Mary Michal 1, and Jewell H. Barrick B.A.1

1 Division of Laboratories, Tennessee Department of Public Health, the Departments of Pediatrics and Pathology, and the Vanderbilt Poliomyelitis Respiratory and Rehabilitation Center, Vanderbilt University School of Medicine

Data has been presented showing that, although 4 months after the third injection of poliomyelitis vaccine, antibody levels were quite high, at 12 months there was a definite and striking decrease in antibody titers.

It is suggested that serious consideration be given to the routine administration of a fourth, 1-ml, injection of poliomyelitis vaccine 12 months after the third injection.

It would seem advisable to follow this practice unless it can be demonstrated that the state and degree of hypersensitivity, without detectable antibodies, is sufficiently great to result in a protective response when natural infection occurs.

Submitted on September 13, 1958
Accepted on October 1, 1958