PEDIATRICS Vol. 23 No. 3 March 1959, pp. 485-492
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PHENOTHIAZINE TRANQUILIZERS AS A CAUSE OF SEVERE SEIZURES

Edward B. Shaw M.D.1, Robert V. Dermott M.D.1, Raymond Lee M.D.1, and T. N. Burbridge M.D., Ph.D.1

1 Departments of Pediatrics and Pharmacology, University of California School of Medicine and the Children's Hospital, San Francisco

The phenothiazine tranquilizer drugs should not be used indiscriminately for symptomatic treatment without due appreciation of the alarming and potentially serious side effects which may follow relatively small doses, especially in childhood. Minimal dosage, due warning to parents of possible symptoms, and careful observation are essential precautions for physicians who use these agents.

Submitted on August 8, 1958
Accepted on September 2, 1958