PEDIATRICS Vol. 23 No. 1 January 1959, pp. 54-62
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ANTIBODY RESPONSE TO INFLUENZA-VIRUS VACCINE IN CHILDREN WITH NEPHROSIS: EFFECT OF CORTISONE

Calvin M. Kunin M.D.1, Robert Schwartz M.D.1, Sumner Yaffe M.D.1, John Knapp M.D.1, Francis X. Fellers M.D.1, Charles A. Janeway M.D.1, and Maxwell Finland M.D.1

1 Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, the Children's Medical Center, and Departments of Medicine and Pediatrics, Harvard Medical School

Polyvalent influenza-virus vaccine was administered to 55 children; 44 of these children were in various stages of nephrotic syndrome, including 17 under treatment with adrenocortical hormones; 5 were children with the adrenogenital syndrome receiving replacement cortisone therapy, and 6 were normal controls.

Antibody response, as measured by the hemagglutination-inhibition test 2 weeks following a single subcutaneous dose of vaccine, was not significantly different in children with active or inactive disease, and appeared to be similar in those receiving hormone therapy and in those who were not.

The serum levels of gamma-globulin were lower in children with active nephrotic syndrome, but this did not affect either the prevaccination levels of influenza A prime antibody or the response to the vaccine.

No change in the status of activity of nephrosis occurred during the period of immunization or immediately thereafter, even in patients who had moderate febrile reactions to the vaccine.

The failure of any of the groups to respond serologically to the Asian strain component of the vaccine is discussed.

Submitted on June 16, 1958
Accepted on July 10, 1958




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