PEDIATRICS Vol. 22 No. 6 December 1958, pp. 1204
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Fatality From Intravenous Nitrofurantoin

AVRON Y. SWEET M.D.1

1 Department of Pediatrics, Mount Sinai Hospital, New York, New York

Recently one patient died and another came near death because of severe metabollic acidosis following the administration of Furadantoin® Intravenous Solution. (The brochure accompanying the medication does not indicate that metabolic disturbances might result from its use.) Both patients were adults with severe and extensive paralysis due to poliomyelitis and marked respiratory paralysis as well. Both had renal calculi and urinary tract infections with bacteria which were resistant to all but the more toxic antibacterial agents.




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 Arch Intern MedHome page
W. R. McCABE, G. G. JACKSON, and H. G. GRIEBLE
Treatment of Chronic Pyelonephritis: II. Short-Term Intravenous Administration of Single and Multiple Antibacterial Agents; Acidosis and Toxic Nephropathy from a Preparation of Intravenous Nitrofurantoin
Arch Intern Med, November 1, 1959; 104(5): 710 - 719.
[Abstract] [PDF]