PEDIATRICS Vol. 22 No. 6 December 1958, pp. 1153-1164
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INFANTILE SPASMS WITH MENTAL RETARDATION

I. Clinical Observations and Dietary Experiments

Niels L. Low M.D.1, James F. Bosma M.D.1, Marvin D. Armstrong Ph.D.1, and Jack A. Madsen M.D.1

1 Department of Pediatrics and the Laboratory for the Study of Hereditary and Metabolic Disorders, University of Utah College of Medicine and the Utah State Department of Health

The clinical syndrome of infantile spasms with mental retardation is described in detail in 10 children. Dietary experiments aimed at attempting to gain evidence for the existence of inborn errors of metabolism in these children did not yield positive information. It is suggested that these children may represent a group who suffer from related, but not yet discovered, metabolic abnormalities.

Submitted on April 11, 1958
Accepted on May 14, 1958




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