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PEDIATRICS Vol. 22 No. 5 November 1958, pp. 875
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Observations in a Case of Hydrocephalus Treated with Diamox®

The effect of Diamox® on the formation of cerebrospinal fluid was studied in a patient with noncommunicating internal hydrocephalus over a period of 1 year. During the administration of Diamox® the frequency of ventricular aspiration was markedly reduced, with long periods when no aspirations were necessary. Percutaneous aspiration of the shunt tube was performed only after signs of increased intracranial pressure developed. Each time the drug was discontinued, signs of increased intracranial pressure soon became evident. Proposals concerning the possible mechanism of drug action, and a brief review of the literature on Diamox® are provided. Confirmation of this observation would be desirable since satisfactory management of this pediatric problem is usually difficult or impossible.


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