PEDIATRICS Vol. 22 No. 4 October 1958, pp. 705
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The Enhancement of Iron Absorption in Rats by D-Sorbitol

Recently investigations have shown that the carbohydrate, D-Sorbitol, enhances the absorption of vitamin B12. Certain amino acids and ascorbic, citric and tartaric acids tend to enhance iron absorption. In view of these findings, the authors undertook to determine the effect of D-sorbitol on iron absorption in the rat. It was found that D-sorbitol causes significant enhancement of the absorption of iron in iron-depleted as well as in normal rats. It was also shown that the amount of iron absorbed increased in proportion to the amount of D-sorbitol administered with the iron. These experiments suggest that the absorption of iron may not be controlled exclusively by the amount of apoferritin in the intestinal mucosa. Possible beneficial or deleterious consequences of the application of these findings to clinical therapy remain to be determined.