PEDIATRICS Vol. 22 No. 4 October 1958, pp. 648-652
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STUDIES ON THE ALLERGENICITY OF COW'S MILK

II. Effect of Heat Treatment on the Allergenicity of Milk and Protein Fractions from Milk as Tested in Guinea Pigs by Parenteral Sensitization and Challenge

Bret Ratner M.D.1, Murray Dworetzky M.D.1, Satoko Oguri B.A.1, and Lydie Aschheim M.S.1

1 Departments of Pediatrics and Microbiology, New York Medical College and Flower and Fifth Avenue Hospitals (B.R., S.O., L.A.) and the Departments of Medicine and Public Health and Preventive Medicine, Cornell University Medical College (M.D.)

As demonstrated by parenteral sensitization and challenge in anaphylaxis experiments with guinea pigs, a particular heat-denatured milk was shown to have lost the allergenicity of the alpha-lactalbumin fraction, partially lost that of the beta-lactoglobulin fraction, and retained the allergenicity of the alpha-casein fraction.

Submitted on February 19, 1958
Accepted on April 8, 1958