PEDIATRICS Vol. 22 No. 3 September 1958, pp. 576-589
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STUDIES ON THE BIOCHEMISTRY OF CONNECTIVE TISSUE

E Mead Johnson Award Address

Albert Dorfman Ph.D., M.D.1

1 La Rabida-University of Chicago Institute and the Department of Pediatrics, University of Chicago

The nature and diversity of acid mucopolysaccharides of connective tissue have been discussed. It is probable that these substances play a variety of physiologic roles.

Insulin affects the rate of synthesis of acid mucopolysaccharides in skin. There is a striking decrease in concentration in the skin of diabetic animals. This is restored toward normal by the administration of insulin.

Acid mucopolysaccharides are excreted in the urine of patients with Hurler syndrome. At least two different polysaccharides are involved. The amount of each in the tissues and urine vary in different patients.




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H. K. Berry
Basic Science Review : The Acid Mucopolysaccharides: These Essential Components of Living Tissue Exhibit Demonstrable Alterations of Diagnostic Assistance in Certain Diseases
Clinical Pediatrics, November 1, 1965; 4(11): 655 - 658.
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