PEDIATRICS Vol. 22 No. 3 September 1958, pp. 494-506
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AVITAMINOSIS E IN CYSTIC FIBROSIS OF THE PANCREAS

A Morphologic Study of Gastrointestinal and Striated Muscle

William A. Blanc M.D.1, Joseph D. Reid M.D.1, and Dorothy H. Andersen M.D.1

1 Babies Hospital and Departments of Pathology and Pediatrics, College of Physicians and Surgeons, Columbia University

Ceroid-pigment is present in the smooth muscle fibers of the gastrointestinal tract of patients with cystic fibrosis of the pancreas. It is first seen during the second year of life. It is found in all patients of 5 years of age and older, and the amount increases with age.

It has not been found in other pediatric conditions with the exception of biliary atresia and cirrhosis of the liver.

Extensive ceroid deposit probably represents an expression of prolonged and severe vitamin-E deficiency, related to protracted malabsorption of fat-soluble tocopherols.

Alterations of striated muscle appear to be rare and minimal in cystic fibrosis of the pancreas.

Submitted on March 10, 1958
Accepted on April 24, 1958




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T. F. Dolan JR
Hemolytic Anemia and Edema as the Initial Signs in Infants with Cystic Fibrosis: Consider This Diagnosis Even in Absence of Pulmonary Symptoms
Clinical Pediatrics, July 1, 1976; 15(7): 597 - 600.
[Abstract] [PDF]