PEDIATRICS Vol. 22 No. 2 August 1958, pp. 309-318
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STUDIES IN SICKLE CELL DISEASE

I. Quantitative Aspects of Sickling in the Newborn Period

George S. Shields M.D.1, Herbert C. Lichtman M.D.1, Jacqueline Messite M.D.1, and R. Janet Watson M.D.1

1 Departments of Medicine and Pediatrics, State University of New York, Downstate Medical Center, and the Kings County Hospital, Brooklyn, New York

In newborn infants with sickle cell trait, the percentage of erythrocytes capable of being sickled in vitro gradually rose during the first 4 months of life. A concomitant fall in the percentage of Hgb F was demonstrated. The percentage of cells which could be induced to assume the sickled shape was found not to be correlated with the percentage of Hgb S, but instead was correlated with the reciprocal of the concentration of Hgb F.

The specific reaction rate of alkali resistant hemoglobin in the infants less than 3 months of age was found to differ from that found in adults and in infants more than 3 months of age.

Submitted on February 28, 1958
Accepted on March 25, 1958