PEDIATRICS Vol. 21 No. 6 June 1958, pp. 963-973
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilson, S. G. F.
Right arrow Articles by Heymann, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilson, S. G. F.
Right arrow Articles by Heymann, W.

AMINONUCLEOSIDE NEPHROSIS IN RATS

S. G. F. Wilson M.B., M.R.C.P., Ed.1, Donald B. Hackel M.D.1, Sargent Horwood 1, Gerald Nash 1, and Walter Heymann M.D.1

1 Department of Pediatrics, Western Reserve University School of Medicine, and Department of Pathology at Cleveland City Hospital

The nephrotic syndrome produced in rats by administration of the aminonucleoside of Puromycin® appears after a latent period which can be shortened or lengthened by increasing or reducing the daily dose. Young rats which survive the initial course lose their proteinuria, but some relapse after 3 to 4 months. Upon re-administration of the nucleoside a chronic disease can be induced which causes death in 3 to 8 months from renal failure. Older rats given a single intravenous injection develop a chronic disease with a natural history the details of which are still not known.

It is unlikely that the pathogenesis is based on an antigen-antibody reaction, since ACTH, cortisone and inhibition of antibody formation by x-radiation fail to prevent the disease.

The nucleoside fails to produce a similar disease in dogs, rabbits, guinea pigs, and mice. Both 3-amino-3-deoxy-D-ribose, and and 6-dimethyl aminopurine, which in combination form the nucleoside, are inactive in producing renal disease individually. It is possible that dogs, rabbits, guinea pigs and mice are able to break down this compound while rats cannot.

Submitted on October 2, 1957
Accepted on January 9, 1958