PEDIATRICS Vol. 21 No. 5 May 1958, pp. 866-867
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Letters to the Editor

SELMA E. SNYDERMAN M.D.

Dr. Milch made some interesting comments about alcaptonuria which, however, are controversial. No attempts were made in my paper, which was a general review article on amino acid metabolism, to explore the various facets of this problem.

First: It would seem to me, that with the demonstration of a defect in a single enzyme system that alcaptonuria is a single disease, not a "syndrome." Alcaptonuric individuals may differ in their clinical manifestations, but the common denominator is the biochemical defect.