PEDIATRICS Vol. 21 No. 2 February 1958, pp. 243-247
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krugman, S.
Right arrow Articles by Ebin, E. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krugman, S.
Right arrow Articles by Ebin, E. V.

IMPROVED LOCAL TOLERANCE TO BENZATHINE PENICILLIN G

Saul Krugman M.D.1 and Eva V. Ebin M.D.1

1 Department of Pediatrics, New York University College of Medicine, and the Children's Medical Service, Bellevue Hospital Center

Four types of penicillin for intramuscular injection were compared for incidence of local reaction: (1) suspension of benzathine penicillin G, 600,000 units in 1 ml; (2) benzathine penicillin G, 600,000 units, with 5 mg of prednisolone, in 1 ml; (3) benzathine penicillin G, 600,000 units, plus aqueous procaine penicillin, 600,000 units, in 2 ml; and (4) aqueous procaine penicillin, 1,200,000 units in 2 ml.

A total of 320 children were evaluated at 24 hours, and the following percentages of severe local reaction were recorded for the four penicillin preparations listed: (1) 54%; (2) 9%; (3) 11.5%; and (4) 4%. The incidence of mild local reactions was the same following all four preparations, 11 to 12%.

The local tolerance to benzathine penicillin G, 600,000 units, was significantly improved by combining it with either 5 mg of prednisolone, or an equal dose and volume of aqueous procaine penicillin.

Submitted on July 22, 1957
Accepted on August 16, 1957




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
H. BEERMAN, L. NICHOLAS, I. L. SCHAMBERG, and M. S. GREENBERG
Review of the Recent Literature
Arch Intern Med, April 1, 1959; 103(4): 621 - 643.
[Abstract] [PDF]