PEDIATRICS Vol. 21 No. 1 January 1958, pp. 40-46
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HEMATOLOGIC STUDIES OF CHILDREN WITH LEAD POISONING

R. Janet Watson M.D.1, Elisabeth Decker M.D.1, and Herbert C. Lichtman M.D.1

1 Departments of Pediatrics and Medicine, State University of New York, College of Medicine at New York City

Thirteen cases of lead poisoning in children were studied hematologically and compared with a similar age group with uncomplicated nutritional iron deficiency anemia. Both groups had a moderate to severe microcytic hypochromic anemia, with a low plasma iron and per cent iron saturation. The group with lead poisoning also had an increase in stippling, target cells and reticulocytes, not present in the other group. The total iron-binding capacity was lower in the lead-poisoning group. The most prominent finding was a great increase in free erythrocyte protoporphyrin in the lead-poisoning group. The group with lead poisoning probably had previous nutritional iron deficiency anemia upon which the lead poisoning had superimposed other hematologic changes. It is not known whether the coincidence of nutritional iron deficiency anemia and lead poisoning has special significance.

Submitted on June 4, 1957
Accepted on July 12, 1957




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