PEDIATRICS Vol. 21 No. 1 January 1958, pp. 13-21
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harris, T. N.
Right arrow Articles by McLean, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harris, T. N.
Right arrow Articles by McLean, D. C.

DETERMINATION OF SOME STREPTOCOCCAL ANTIBODY TITERS AND ACUTE PHASE REACTANTS IN PATIENTS WITH CHOREA

T. N. Harris M.D.1, Sidney Friedman M.D.1, and David C. McLean M.D.1

1 Rheumatic Fever Research Laboratory of the Children's Hospital of Philadelphia, the Philadelphia General Hospital, the Hospital of the University of Pennsylvania and the Department of Pediatrics, School of Medicine, University of Pennsylvania

Forty-three patients with chorea were examined by a number of laboratory tests: These consisted of two streptococcal serologic titrations, antistreptolysin-O and antihyaluronidase, and three acute phase tests, the erythrocyte sedimentation rate, and the concentrations of C-reactive protein and mucoproteins in the serum. The patients were divided into two groups, those with apparently "pure" chorea, who did not show any other clinical evidence of rheumatic fever in conjunction with an episode of chorea, or at any other time to our knowledge, and those with some other evidence of rheumatic fever. In the case of each of these tests the frequency distribution of values found in the rheumatic chorea group was different from that of the "pure" chorea group, the former having a higher center and range of distribution. Also, the results of both the acute phase tests and the streptococcal serologic tests gave evidence of contamination of the "pure" chorea group with rheumatic subjects.

The data suggest that there are, in fact, two such clinical groups of patients with chorea, and that laboratory aid toward the differential diagnosis between them would be applied in the same way as in other differential diagnoses involving rheumatic fever.

Submitted on May 27, 1957
Accepted on July 12, 1957