PEDIATRICS Vol. 20 No. 1 July 1957, pp. 87-91
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TREATMENT OF MEASLES ENCEPHALITIS WITH ADRENAL STEROIDS

John E. Allen M.D.1

1 The Contagious Division, Cincinnati General Hospital, and the Department of Pediatrics, College of Medicine, University of Cincinnati

Ten cases of measles encephalitis treated with large doses of adrenal steroids are presented. Apparent complete recovery occurred in all 10 cases. In most of the cases clinical improvement was dramatic and prompt. There was no evidence of untoward reaction from the use of steroids combined with prophylactic antibiotic therapy. The results in this series are further substantiated by the report of Appelbaum and Abler who reported the recovery of 16 out of 17 patients with adrenocorticotropin.

It is to be emphasized that measles encephalitis is an extremely variable disease and that only prolonged experience with one form of therapy by different investigators and clinicians can determine the final efficacy of the treatment. Ten cases are not a great number from which to draw a definite conclusion in this disease, however, the results were so convincing to us that we felt an early publication of this information worthwhile in the hope that further trials will be undertaken by other groups. From our experience we recommend the treatment of measles encephalitis with steroid therapy as outlined.

Submitted on October 5, 1956
Accepted on January 8, 1957




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