PEDIATRICS Vol. 2 No. 4 October 1948, pp. 410-414
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IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN, WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

IV. Occurrence of Agglutinins in Normal and Abnormal Conditions

PAUL F. DEGARA M.D.1

1 The New York Hospital and the Department of Pediatrics, Cornell University Medical College.

Agglutinative antibodies for three different strains Str. hemolyticus, beta, group A, were studied in 497 sera from 372 children. A high titer was found in approximately 9% of well children.

There was no significant difference between rheumatic and non-rheumatic subjects in the incidence of high agglutinin titers for Str. hemolyticus.

Following infections, presumably streptococcal in origin, approximately 46% of the children examined had high agglutinin titers for Str. hemolyticus.

In active rheumatic fever, agglutinins were present in high titers in nine out of 11 patients who had experienced an antecedent illness, presumably streptococcal in origin. Of 23 patients with no history of such an infection, only three had streptococcal agglutinins.

Submitted on June 8, 1948