PEDIATRICS Vol. 2 No. 2 August 1948, pp. 190-199
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POLIOMYELITIS IN FAMILIES ATTACKED BY THE DISEASE

II. The Presence, Appearance, and Persistence of Neutralizing Antibodies

HERBERT A. WENNER M.D.1 and WILLIAM A. TANNER M.D.2

1 The Department of Pediatrics, and the Hixon Memorial Laboratory, University of Kansas School of Medicine, Kansas City, Kan.
2 The Department of Bacteriology, and the Hixon Memorial Laboratory, University of Kansas School of Medicine, Kansas City, Kan.

A study has been made concerning the presence, and persistence of neutralizing antibodies to poliomyelitis virus in six individuals. Five individuals had poliomyelitis; the remaining subject was a familial contact.

Neutralizing antibodies do appear in the serums of patients convalescent from poliomyelitis. In this study neutralizing antibodies, as a rule, appeared during the first ten days of illness. There is the suggestion that these antibodies appear rapidly, quickly reach their highest level, and that there is little if any fall in titer during the ensuing year.

The neutralizing antibody titer may not reach a high level in a considerable number of patients.

Submitted on April 27, 1948




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