PEDIATRICS Vol. 2 No. 1 July 1948, pp. 35-42
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CLINICAL USE OF ALCOHOL-REFINED TOXOIDS

J. M. RUEGSEGGER M.D. and G. K. LOOSER M.D.

Alcohol-refined toxoids of diphtheria and tetanus were inoculated into 31 adults and 550 children.

These alum-precipitated toxoids are associated with many fewer and less severe reactions, both in adults and children, than those following the use of ordinary toxoids.

Within the limits of a year's observation after inoculation, such toxoids appear to be able to stimulate an adequate and durable immunity as adjudged by serial antitoxin titrations.

Submitted on April 19, 1948