PEDIATRICS Vol. 2 No. 1 July 1948, pp. 30-34
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SEVERE ERYTHEMA MULTIFORME OF THE PLURIORIFICIAL TYPE (STEVENS-JOHNSON SYNDROME)

Resulting in Blindness in a Patient Treated with Trimethadione (Tridione)

BERTRAM SHAFFER M.D.1 and PAUL MORRIS M.D.1

1 The Dermatologic Service and Pediatric Service #2 of the Mt. Sinai Hospital.

A case of severe erythema multiforme of the pluriorificial type resulted in total complete blindness due to bilateral involvement of the cornea.

This eruption followed the administration of trimethadione and anterior pituitary extract. The possibility that trimethadione was the cause of the syndrome was considered.

Submitted on May 11, 1948