PEDIATRICS Vol. 17 No. 4 April 1956, pp. 471-481
This Article
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stempfel, R.
Right arrow Articles by Zetterström, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stempfel, R.
Right arrow Articles by Zetterström, R.

OBSTRUCTIVE JAUNDICE COMPLICATING HEMOLYTIC DISEASE OF THE NEWBORN

Robert Stempfel M.D.1, Birger Broman M.D.1, Florencio E. Escardó M.D.1, and Rolf Zetterström M.D.1

1 Department of Pediatrics, Karolinska Sjukhuset, Stockholm, Sweden

In a consecutive series of 83 Rh-isoimmunized infants, 7 had significantly elevated levels (greater than 1.0 mg./100 ml.) of direct bilirubin in the cord blood and developed obvious biliary obstruction. In no instance was a low concentration of direct bilirubin in the cord blood associated with the development of this condition. Serially determined electrophoretic separations of the serum proteins in 6 of the 7 patients revealed patterns not unlike those seen in the normal infant.

In exchange transfusions calculated to remove 85 per cent of the infant's blood, the total bilirubin concentration of the serum was reduced 30 to 50 per cent in infants with and in those without biliary obstruction. However, for the purpose of maintaining the total bilirubin concentration below "critical" levels, it was found that exchange therapy is less efficient, from a temporal standpoint, in infants whose hemolytic disease is complicated by biliary obstruction.

The cause of intrahepatic biliary obstruction is discussed and the prognostic value of the concentration of direct bilirubin in the cord blood of erythroblastotic infants is stressed.

Submitted on August 8, 1955
Accepted on September 9, 1955




This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
C.W. Reiquam, E.C. Beatty JR, and J. R. Connell
Erythroblastosis Fetalis: Elevated Conjugated Bilirubin, Anemia and Liver Necrosis Relationships and Clinical Implications
Clinical Pediatrics, July 1, 1967; 6(7): 411 - 421.
[Abstract] [PDF]