PEDIATRICS Vol. 17 No. 1 January 1956, pp. 72-77
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NEONATAL THROMBOCYTOPENIC PURPURA

Edgar J. Schoen M.D.1, Alexander L. King M.D.1, and Rose T. Duane A.B.1

1 Department of Pediatrics, Kaiser Foundation Hospital, and Rh Laboratory, University of California Medical School

A case of neonatal thrombocytopenic purpura in the newborn infant of a mother with idiopathic thrombocytopenic purpura is reported. The mother and the baby both had platelet autoagglutinins, and isoagglutinins were present for each other's platelets. The infant's agglutinins had disappeared by the age of 3 months. Cortisone administration had no definite effect on the thrombocytopenia in the baby. It is believed that this case offers further evidence that neonatal thrombocytopenic purpura is due largely to transmission across the placental membranes of maternal platelet antibodies which lead to destruction of the infant's platelets and to purpura. The possible use of exchange transfusion in neonatal thrombocytopenic purpura is briefly discussed.