PEDIATRICS Vol. 15 No. 4 April 1955, pp. 402-412
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Uhlmann, E. M.
Right arrow Articles by von Essen, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uhlmann, E. M.
Right arrow Articles by von Essen, C.

NEUROBLASTOMA (NEUROBLASTOMA SYMPATHETICUM)

Erich M. Uhlmann M.D., F.A.C.R.1 and Carl von Essen M.D.2

1 The Tumor Clinic of Michael Reese Hospital, Chicago, Illinois.
2 The Tumor Clinic of Michael Reese Hospital, Chicago, Illinois., Trainee, National Cancer Institute.

It has been shown that neuroblastoma can be controlled by irradiation even after extensive spread. It must be agreed that in some instances it is highly unlikely that cancerocidal doses could have reached all the tumor cells. With the knowledge that this tumor may occasionally spontaneously regress or mature into a benign ganglioneuroma, it may be postulated that irradiation can promote or accelerate the process of maturation. To our knowledge there have been no follow-up histological studies in cured individuals. This would be of great value if biopsy of the liver or other previously involved organs could be made perfectly safe. The report of patients showing arrest and regression of disease after chemotherapy should also stimulate further interest in tile biological behavior of this unusual tumor.

Unquestionably, radiation does arrest and control this disease by direct cancerocidal action. However, the favorable results in a few instances of disseminated neoplasm render further clinical investigations highly important in solving the riddle of its biological behavior.

Submitted on September 1, 1954
Accepted on December 22, 1954