PEDIATRICS Vol. 14 No. 5 November 1954, pp. 495-504
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RETICULOENDOTHELIOSIS AND MYELOPROLIFERATIVE DISORDERS

Presentation of a Case Intermediate Between These Disorders and a Discussion of Their Interrelationships

HENRY K. SILVER M.D.1

1 The Department of Pediatrics, Yale University School of Medicine.

1. The case of a three-year-old boy is presented who had hepatosplenomegaly, bleeding manifestations, reticulocytosis, marked thrombocytopenia and leukocytosis and in whom abnormal cells of various types were found in the peripheral blood. These abnormal cells included nucleated red cells, young myeloid forms as well as immature monocytes. The bone marrow was characterized by a marked increase of nucleated red cells, in all stages of developments, as well as by a moderate increase of mature and immature monocytes.

2. This case appeared to be related clinically to: (1) erythroleukemia; (2) leukoerythroblastosis; (3) monocytic leukemia, both of the Naegeli type and (4) of the Schilling type with leukomoid reaction; (5) leukemic reticuloendotheliosis, and (6) patient No. VII of Downey.

3. The interrelationships between these disorders is discussed.

Submitted on March 16, 1954