PEDIATRICS Vol. 14 No. 4 October 1954, pp. 357-363
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THE TREATMENT AND PREVENTION OF EPIDEMIC INFANTILE DIARRHEA DUE TO E. COLI 0-111 BY THE USE OF CHLORAMPHENICOL AND NEOMYCIN

WARREN E. WHEELER M.D.1 and BERTHA WAINERMAN M.D.1

1 The Departments of Pediatrics and Bacteriology, Ohio State University and The Children's Hospital, Columbus, Ohio.

Table IV represents a summary of our findings regarding the use of these two antibiotic drugs. We feel that both were effective in reducing the severity of the diarrhea, but that chloramphenicol was followed by the emergence of a distressing number of drug resistant strains of organisms which made it less satisfactory at the dosage level used than neomycin. An attempt to prevent cross infections by the prophylactic use of chloramphenicol failed. We would like to emphasize the relapsing nature of the disease, the need for special techniques to recognize the organism, its great transmisibility, and would caution others who treat outbreaks of this infection with antibiotics to be mindful of the need to watch for the development of drug resistant strains of the organism. Since neomycin appears to act in vivo as a bactericidal drug, it would seem to have theoretical as well as practical advantages over the broad spectrum antibiotic drugs in the treatment of this disease.[SEE TABLE IV IN SOURCE PDF.]

Submitted on May 27, 1954