PEDIATRICS Vol. 13 No. 4 April 1954, pp. 319-325
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BILIRUBIN ENCEPHALOPATHY

WILLIAM J. WATERS M.D.1, DAN A. RICHERT PH.D.1, and HELEN H. RAWSON M.D.1

1 The Departments of Pediatrics and Biochemistry of the State University of New York Medical Center, Syracuse, N.Y.

Peripheral blood specimens from cases of varying degree of clinical severity of hemolytic disease of the newborn infant have been examined spectrophotometrically and a curve consistent with the presence of bilirubin was found in each case.

Extracts of the pigmented brain areas from five cases of hemolytic disease of the newborn infant, who died with clinical signs of brain damage, were examined spectrophotometrically and in each intance a curve consistent with bilirubin was obtained. An extract from comparable sections of brain not appearing grossly pigmented contained essentially no such pigment when examined spectrophotometrically.

Crystals were obtained from a chloroform extract of pigmented brain areas and when re-dissolved showed a typical type curve for bilirubin.

A positive van den Bergh was obtained on the extract solution.




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