PEDIATRICS Vol. 13 No. 4 April 1954, pp. 308-318
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SLATER, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SLATER, R. J.

INVESTIGATION OF AN INFANT BORN OF A MOTHER SUFFERING FROM CIRRHOSIS OF THE LIVER

ROBERT J. SLATER M.D.1

1 The Hospital of The Rockefeller Institute for Medical Research, New York City.

The successful pregnancy and uncomplicated ated delivery of a healthy infant by a young woman suffering from severe cirrhosis of the liver is described.

Serial liver function studies in the infant during the neonatal period suggested a degree of hepatic immaturity not dissimilar from that observed in normal newborn infants.

Maternal serum alterations are compared with fetal and neonatal findings. Electrophoretic analysis revealed that the fetus had a normal albumin concentration despite a low level in the mother. The serum ggr-globulin was elevated in the fetus just as it was in the mother. Serum bilirubin was present in only frac12 the concentration in the fetus as in the mother. Differences in lipoproteins and other high molecular weight components were found. The role of placental permeability in relation to these variations is discussed.

Serial electrophoretic analyses during the neonatal period indicated a normal catabolic rate for the unusually elevated ggr-globulin component in the infant [tfrac12=20 days].