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Published online August 10, 2009
PEDIATRICS Vol. 124 No. 3 September 2009, pp. 972-979 (doi:10.1542/peds.2008-3724)
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SPECIAL ARTICLE

Failure to Thrive: When to Suspect Inborn Errors of Metabolism

Can Ficicioglu, MD, PhD, Kristina an Haack, MD

Section of Biochemical Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Failure to thrive (FTT) is a common symptom, not a diagnosis, of a wide range of childhood diseases. Although FTT is usually caused by inadequate energy intake in diet or constitutional small size, organic pathology should be considered in some cases of FTT. This article is intended to guide primary care physicians for when to suspect inborn errors of metabolism in children who present with FTT.

Key Words: failure to thrive • metabolic disorders

Abbreviations: FTT—failure to thrive • IEM—inborn error of metabolism • GSD—glycogen-storage disease

Accepted Feb 27, 2009.


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